IL-7 exacerbates chronic colitis with expansion of memory IL-7R CD4 mucosal T cells in mice
نویسندگان
چکیده
Eriko Okada,* Motomi Yamazaki,* Masanobu Tanabe, Tsutomu Takeuchi, Masanobu Nanno, Shigeru Oshima, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Takanori Kanai, Toshifumi Hibi, and Mamoru Watanabe Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo; Departments of Tropical Medicine and Parasitology and Internal Medicine, School of Medicine, Keio University, Tokyo; and Yakult Central Institute for Microbiological Research, Kunitachi City, Tokyo, Japan
منابع مشابه
IL-7 exacerbates chronic colitis with expansion of memory IL-7Rhigh CD4+ mucosal T cells in mice.
We have previously demonstrated that mucosal CD4(+) T cells expressing high levels of IL-7 receptor (IL-7R(high)) are pathogenic cells responsible for chronic colitis. Here we investigate whether IL-7 is directly involved in the expansion of IL-7R(high) memory CD4(+) mucosal T cells and the exacerbation of colitis. We first showed that CD4(+) lamina propria lymphocytes (LPLs) from wild-type, T ...
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Although IL-7 has recently emerged as a key cytokine involved in controlling the homeostatic turnover and the survival of peripheral resting memory CD4(+) T cells, its potential to be sustained pathogenic CD4(+) T cells in chronic immune diseases, such as inflammatory bowel diseases, still remains unclear. In this study, we demonstrate that IL-7 is essential for the development and the persiste...
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